To achieve favorable outcomes in breeding programs, selection of parents based on General Combining Ability (GCA) and Specific Combining Ability (SCA) is so important. In order to study the genetic parameters, general and specific combining abilities and the type of DISEASE RESISTANCE genes action against take-all DISEASE in bread wheat, 6 wheat genotypes (729, 1622, 2109, 1528, 1546 and 1526) were crossed in one-way diallel cross. Seeds of F1 generations (F1s) and parents were planted in the research greenhouse of Vali-e-Asr University of Rafsanjan, Iran and take-all DISEASE tolerance, stem and root dry weights, tiller number and elements such as manganese (Mn), zink (Zn), potassium (K) and iron (Fe) concentrations in plant tissue were measured. The results of Griffing analysis showed that general and specific combining abilities were significant for all traits except tiller number and K element. In terms of Take-all DISEASE RESISTANCE, the best general combiners were 1622 and 729 genotypes, respectively. The best resistant hybrids were 2109×1546, 546×1528 and 1622×1526 that had the highest specific combining ability. Evaluation of genetic parameters by Hayman method for DISEASE index and DISEASE score confirmed the results of Griffing analysis and showed that the dominance and over dominance of gene actions had the greatest importance in genetic control of the RESISTANCE to take-all DISEASE (T-41 isolation). Finally, due to low narrow sense heritability and low genetic ratio in RESISTANCE to take-all DISEASE, it can be concluded that selection for RESISTANCE to take-all DISEASE does not respond well in early generations, so selection after purity, that done by bulk, single-seed descent and double haploid methods can be effective in wheat breeding.

For development of parental pollinators of sugar beet resistant to powdery mildew DISEASE, a rather resistant 14442 population was used. Based on the RESISTANCE index, 50 resistant plants were selected to produce half sib families (H.S.F). After open pollinating between these 50 plants, seeds of H.S.F were harvesed. Among these 50 plants, 39 plants produced enough seed. This H.S.F were planted in one raw plot with six replications and evaluated for DISEASE RESISTANCE in the next year. Three H.S.Fs (H.S.F13, H.S.F24 and H.S.F35) with high level of RESISTANCE were selected. These three families were expressed to selection 150 roots were selected to produce next half sib families. Among these 150 families, 88 roots produced enough seed. In the next cycle, 88 new H.S.F were evaluated for DISEASE RESISTANCE and three H.S.Fs (H.S.F5, H.S.F17 and H.S.F22) with high level of RESISTANCE were selected. From each H.S.F, 35 roots were selected to produce S1 lines. In the cage, among 105 roots, only 13 plants produced enough seed. 13 S1 were evaluated again for DISEASE RESISTANCE in the next year. Low level of infection (12.9 %) was observed in the S1 lines. Therefore, selection in the 14442 population for powdery mildew RESISTANCE was very effective, and the plants selected in this method showed 72.6 % selection progress. Because of the high RESISTANCE of the S1 lines, they could be used to develop powdery mildew resistancte varieties.

Introduction. This fascinating disorder is also known as Sinus Histiocytosis. It is very rare, probably less than 1000 cases reported in the literature. R.D.D affects lymph nodes, although extranodal involvement has been reported such as: Centaral nervous system (CN.S). All of the cases of R.D.D with CN.S involvement without other sites involvement are 11 cases. Methods. The case is a male patient, 26y/o, with a history of head trauma 2 years ago that has been resulted to unconsciousness. He has been referred to a hospital and brain CT scan and brain M.R.I has been done for him. In M.R.I a brain tumor with left orbit and sphenoidal sinus involvement and compression effect on frontal lobe has been seen. A neurosurgeon operated him and the pathological report was Rosai-Dorfman DISEASE. Then he was referred to radiation therapy department.Results. Treatment approach in CN.S involvement cases consists of surgery, radiotherapy and chemotherapy. Discussion. Over all, response has been inferior to those expected with malignant hematopoietic neoplasms.

In 2019 a newly emerged coronavirus was detected by the Center for DISEASE control (CDC) in China. Nucleic acid sequencing from nose and throat swab samples of patients revealed that it was like severe acute respiratory syndrome coronavirus (SARS-CoV). World Health Organization (WHO) named it coronavirus DISEASE 2019 (COVID-19) and reported more than 100000 positive tests until March 2020 for COVID-19. During the past 20 years, the world has been affected by three coronavirus epidemics, SARS-COV, Middle East respiratory syndrome coronavirus (MERS-CoV), and COVID-19 that make world attention. The mortality rate of COVID-19 was more than other coronaviruses, but because of more people affected by it, it seems that it has a less fatality rate compared with MERS-CoV. Initial data showed that more than 80% of patients did not have any symptoms or may had light symptoms. 15% showed severe pneumonia, 5% became critically ill, and developed multiorgan dysfunction and septic shock. Due to the epidemic of emerging viruses and the lack of information about it, this study aimed to provide a quick overview of the most recent studies in the world. To perform this review, keywords such as COVID-19, severe acute respiratory syndrome coronavirus 2, and Angiotensin-converting enzyme 2 were retrieved using the medical subject headings (MeSH) system and then searched in English in PubMed, Scopus, Google Scholar, and Web of Science databases. COVID-19 virus enters its genome into the cells by binding to Angiotensin-converting enzyme 2 in some organs such as the lungs. Although the transmission route is unclear, it enters the body through respiratory droplets. The clinical symptoms includ fever, cough, dyspnea, myalgia, confusion, headache, sore throat, rhinorrhea, chest pain, diarrhea, nausea, vomiting, malaise, and convulsion. The standard diagnostic method is Real-time polymerase chain reaction (RT-PCR), but due to the time-consuming and sensitivity and the existing errors in this technique, chest CT and hematologic data are preferred. No definitive cure for the virus has been suggested so far, but antiviral drugs such as Oseltamivir, Ganciclovir, Lopinavir, Ritonavir and Remdesivir, and the anti-malarial drug Chloroquine phosphate and Interferon are in use until the discovery of the vaccine.

2Background: Antibiotic RESISTANCE represents a critical global concern within the medical community, posing significant challenges in the treatment of infections caused by drug-resistant pathogens. Over the years, broad-spectrum fluoroquinolones have been extensively used to treat infections caused by both Gram-positive and Gram-negative bacteria, including Pseudomonas aeruginosa. In this study, we decided to assess the prevalence of plasmid-mediated quinolone RESISTANCE mechanisms among clinical isolates of P. aeruginosa in Ardabil hospitals. Methods: We analyzed a total of 200 clinical isolates of P. aeruginosa, collected between June 2019 and May 2023. The antibiotic RESISTANCE profiles of these strains against various fluoroquinolone antibiotics were determined using the disk diffusion method. Additionally, we investigated the presence of qnrA, qnrB, qnrC, qnrD, and qnrS genes through polymerase chain reaction (PCR) analysis. Furthermore, we assessed the expression levels of efflux pump genes and outer membrane porin genes using the quantitative reverse transcription PCR (qRT-PCR) in fluoroquinolone-resistant P. aeruginosa strains. Results: Our findings revealed that 69% of P. aeruginosa strains were resistant to fluoroquinolones. The RESISTANCE rates for different fluoroquinolones were as follows: ciprofloxacin 55.5%, ofloxacin 62%, norfloxacin 53.5%, lomefloxacin 55.3%, and levofloxacin 55.5%. Notably, 78.9% of these strains exhibited multidrug RESISTANCE (MDR). Among the qnr genes, qnrB was the most prevalent (2.9%). No other qnr genes were identified. Interestingly, 75% of P. aeruginosa strains carrying the qnrB gene showed overexpression of efflux pump genes, while 100% exhibited down-regulation of the oprD gene. Conclusion: Given the high prevalence of fluoroquinolone-resistant P. aeruginosa clinical isolates in Ardabil hospitals and the multifactorial nature of RESISTANCE, continuous monitoring of antibiotic RESISTANCE trends and understanding the underlying RESISTANCE mechanisms are crucial for selecting appropriate treatment strategies.

Fahr’s DISEASE is a progressive and idiopathic basal ganglia calcification with normal metabolism of calcium and phosphore with motor and psychiatric sings and symptoms. Dementi, chorea attetosise, psychosis and depression due to Fahr’s DISEASE are frequently reported, but Fahr’s DISEASE with bipolar mood disorder manifestation is very rare and we found only 3 cases in review of literature from 1995 to 2005. In this case report, a 21-years old girl is presented who was admitted to Sari-Zare psychiatric hospital for aggression, restlessness and insomnia. After mental status examination and paraclinical investigation, bipolar mood disorder due to Fahr’s DISEASE was detected. To date no specific treatment was found for this DISEASE. This point is important that the patients with Fahr’s DISEASE are sensitive to neuroleptic malignant syndrome.